Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men.
Scand J Med Sci Sports
; 27(7): 684-691, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-27060857
ABSTRACT
While chronic systemic administration of glucocorticoids increases muscle Na+ ,K+ ATPase content, such effect is unexplored after therapeutic inhalation. We investigated the effect of therapeutic inhalation of the glucocorticoid budesonide on Na+ ,K+ ATPase content of skeletal muscle in men. Ten healthy trained subjects, aged 23 ± 4 years (mean ± 95% CI), participated in the study. Before and after 2 weeks of daily inhalation of budesonide (1.6 mg/day), a biopsy was taken from the vastus lateralis muscle for measurement of Na+ ,K+ ATPase content and blood samples were drawn for determination of plasma budesonide, cortisol, and K+ . Subjects' performance during cycling to fatigue at 90% of incremental peak power output (iPPO) was measured in response to 4 mg inhaled terbutaline to maximally stimulate Na+ ,K+ ATPase activity. Plasma concentrations of budesonide rose to 5.0 ± 1.6 nM with the intervention, whereas no changes were observed in plasma cortisol. Muscle Na+ ,K+ ATPase content increased (P ≤ 0.01) by 46 ± 34 pmol/(g wet wt) (17% increase) with the intervention. Cycling performance at 90% of iPPO did not change (P = 0.21) with the intervention (203 vs 214 s) in response to terbutaline. The present observations show that therapeutic inhalation of glucocorticoids increases muscle Na+ ,K+ ATPase content, but does not enhance high-intensity cycling endurance in response to terbutaline.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência Física
/
Terbutalina
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Exercício Físico
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ATPase Trocadora de Sódio-Potássio
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Budesonida
/
Músculo Quadríceps
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Humans
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Male
Idioma:
En
Revista:
Scand J Med Sci Sports
Assunto da revista:
MEDICINA ESPORTIVA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Dinamarca