Serralongamines B-D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages.

Ishiuchi, Kan'ichiro; Jiang, Wen-Ping; Fujiwara, Yukio; Wu, Jin-Bin; Kitanaka, Susumu

Ishiuchi, Kan'ichiro; Jiang, Wen-Ping; Fujiwara, Yukio; Wu, Jin-Bin; Kitanaka, Susumu.

Afiliação

Ishiuchi K; School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi 274-8555, Chiba, Japan; Graduate School of Pharmaceutical Sciences, Nagoya-City University, 3-1, Tanabe-Dori, Mizuho-ku, Nagoya 467-8603, Aichi, Japan.
Jiang WP; School of Pharmacy, China Medical University, No. 91, Hsueh-Shih R., Taichung 40402, Taiwan.
Fujiwara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Kumamoto, Japan.
Wu JB; School of Pharmacy, China Medical University, No. 91, Hsueh-Shih R., Taichung 40402, Taiwan. Electronic address: jbwu@mail.cmu.edu.tw.
Kitanaka S; School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi 274-8555, Chiba, Japan. Electronic address: kitanaka.susumu@nihon-u.ac.jp.

Bioorg Med Chem Lett ; 26(11): 2636-40, 2016 06 01.

Article em En | MEDLINE | ID: mdl-27086123

ABSTRACT

ABSTRACT

Three new Lycopodium alkaloids, serralongamines B-D (1-3), have been isolated from the club moss Lycopodium serratum var. longipetiolatum, and the structures were elucidated on the basis of spectroscopic data and chemical transformation. 1 and 3 significantly exhibited the inhibitory activity against foam cell formation in human macrophages, one of characteristic features of early atherosclerotic lesions.

Assuntos

Células Espumosas/efeitos dos fármacos; Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia; Lycopodium/química; Macrófagos/efeitos dos fármacos; Quinolinas/farmacologia; Relação Dose-Resposta a Droga; Compostos Heterocíclicos de 4 ou mais Anéis/química; Compostos Heterocíclicos de 4 ou mais Anéis/isolamento & purificação; Humanos; Estrutura Molecular; Quinolinas/química; Quinolinas/isolamento & purificação; Relação Estrutura-Atividade

Palavras-chave

Atherosclerosis; Foam cells; Human monocyte-derived macrophages; Lycopodium alkaloids; Lycopodium serratum var. longipetiolatum; Serralongamines B, C and D

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Lycopodium / Células Espumosas / Compostos Heterocíclicos de 4 ou mais Anéis / Macrófagos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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