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Lipophilic nalmefene prodrugs to achieve a one-month sustained release.
Gaekens, Tim; Guillaume, Michel; Borghys, Herman; De Zwart, Loeckie L; de Vries, Ronald; Embrechts, Roger C A; Vermeulen, An; Megens, Anton A H P; Leysen, Josée E; Herdewijn, Piet; Annaert, Pieter P; Atack, John R.
Afiliação
  • Gaekens T; API Small Molecule Development, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Guillaume M; API Small Molecule Development, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Borghys H; Neuroscience, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • De Zwart LL; Drug Metabolism and Pharmacokinetics, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • de Vries R; Drug Metabolism and Pharmacokinetics, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Embrechts RC; Drug Product Development, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Vermeulen A; Clinical Pharmacology, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Megens AA; Neuroscience, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Leysen JE; Neuroscience, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium; Department of Nuclear Medicine and PET Research, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
  • Herdewijn P; Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Box 1030, B-3000 Leuven, Belgium.
  • Annaert PP; Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, O&N2, Herestraat 49-Box 921, B-3000 Leuven, Belgium.
  • Atack JR; Neuroscience, Janssen Pharmaceuticals, Turnhoutseweg 30, B-2340 Beerse, Belgium. Electronic address: J.Atack@Sussex.ac.uk.
J Control Release ; 232: 196-202, 2016 06 28.
Article em En | MEDLINE | ID: mdl-27107723
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbamatos / Pró-Fármacos / Ácidos Graxos / Glutaratos / Naltrexona / Antagonistas de Entorpecentes Limite: Animals Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbamatos / Pró-Fármacos / Ácidos Graxos / Glutaratos / Naltrexona / Antagonistas de Entorpecentes Limite: Animals Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Bélgica