Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1&#945;/p300 Interaction.

Goey, Andrew K L; Chau, Cindy H; Sissung, Tristan M; Cook, Kristina M; Venzon, David J; Castro, Amaya; Ransom, Tanya R; Henrich, Curtis J; McKee, Tawnya C; McMahon, James B; Grkovic, Tanja; Cadelis, Melissa M; Copp, Brent R; Gustafson, Kirk R; Figg, William D

Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.

Goey, Andrew K L; Chau, Cindy H; Sissung, Tristan M; Cook, Kristina M; Venzon, David J; Castro, Amaya; Ransom, Tanya R; Henrich, Curtis J; McKee, Tawnya C; McMahon, James B; Grkovic, Tanja; Cadelis, Melissa M; Copp, Brent R; Gustafson, Kirk R; Figg, William D.

Afiliação

Castro A; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702-1201, United States.
Ransom TR; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702-1201, United States.
Henrich CJ; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702-1201, United States.
McKee TC; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702-1201, United States.
McMahon JB; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702-1201, United States.
Grkovic T; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702-1201, United States.
Cadelis MM; School of Chemical Sciences, University of Auckland , Auckland 1142, New Zealand.
Copp BR; School of Chemical Sciences, University of Auckland , Auckland 1142, New Zealand.
Gustafson KR; School of Chemical Sciences, University of Auckland , Auckland 1142, New Zealand.
Figg WD; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702-1201, United States.

J Nat Prod ; 79(5): 1267-75, 2016 05 27.

Article em En | MEDLINE | ID: mdl-27140429

Assuntos

Alcaloides/farmacologia; Proteína p300 Associada a E1A/antagonistas & inibidores; Subunidade alfa do Fator 1 Induzível por Hipóxia/antagonistas & inibidores; Poríferos/química; Pirroliminoquinonas/farmacologia; Alcaloides/química; Animais; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Células HCT116; Compostos Heterocíclicos de 4 ou mais Anéis; Humanos; Masculino; Biologia Marinha; Estrutura Molecular; Neovascularização Patológica; Neoplasias da Próstata/tratamento farmacológico; Pirroliminoquinonas/química; Quinonas; Compostos de Espiro; Tiazepinas; Fator A de Crescimento do Endotélio Vascular/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Pirroliminoquinonas / Alcaloides / Proteína p300 Associada a E1A / Subunidade alfa do Fator 1 Induzível por Hipóxia Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans / Male Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article

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