The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats.
Folia Med (Plovdiv)
; 57(3-4): 235-42, 2015.
Article
em En
| MEDLINE
| ID: mdl-27180351
ABSTRACT
UNLABELLED The AIM of this experimental study was to evaluate the effect of the antioxidant drug "U-74389G" in a rat model of hypoxia reoxygenation (HR) using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW) levels. MATERIALS AND METHODS:
40 rats of a mean weight of 231.875 g were employed in the study. RDW levels were determined at 60 min (groups A and C) and at 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G.RESULTS:
demonstrated that U-74389G administration significantly decreased the RDW levels by 4.96% + 2.27% (p = 0.0175). Reoxygenation time non-significantly decreased the RDW levels by 0.27% + 2.41% (p = 0.8889). Together, U-74389G administration and reoxygenation time non-significantly decreased the RDW levels by 2.54% + 1.39% (p = 0.0679).CONCLUSIONS:
U-74389G administration particulary in concert without reperfusion declines the RDW levels even within the short - time context of 1.5 hours reperfusion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pregnatrienos
/
Traumatismo por Reperfusão
/
Índices de Eritrócitos
/
Hipóxia
/
Antioxidantes
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
Folia Med (Plovdiv)
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Grécia