Low DLCO in idiopathic pulmonary arterial hypertension - clinical correlates and prognostic significance.
Pneumonol Alergol Pol
; 84(2): 87-94, 2016.
Article
em En
| MEDLINE
| ID: mdl-27238166
ABSTRACT
INTRODUCTION:
Decreased diffusing capacity of the lung for carbon monoxide (DLCO) is observed in some idiopathic pulmonary arterial hypertension (IPAH) patients, but its clinical significance is uncertain. We aimed to assess clinical correlates and prognostic significance of low DLCO in IPAH patients. MATERIAL ANDMETHODS:
In the group of 65 IPAH patients the cut off value for low DLCO was set up based on histogram as < 55% of predicted value. Demographic data, exercise capacity, lung function tests, hemodynamic parameters and survival of the patients were compared depending on DLCO value.RESULTS:
Low DLCO was found in 18% of the patients, and it was associated with male sex, older age, worse functional status and exercise capacity, and higher prevalence of coronary artery disease. Low DLCO carried a 4-fold increase of death risk in 5-year perspective.CONCLUSIONS:
Low DLCO was a marker of worse functional capacity and increased risk of death in studied IPAH patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monóxido de Carbono
/
Capacidade de Difusão Pulmonar
/
Hipertensão Pulmonar Primária Familiar
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
/
Female
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Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pneumonol Alergol Pol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article