Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation.

Ng, Chai-Ann; Gravel, Andrée E; Perry, Matthew D; Arnold, Alexandre A; Marcotte, Isabelle; Vandenberg, Jamie I

Ng, Chai-Ann; Gravel, Andrée E; Perry, Matthew D; Arnold, Alexandre A; Marcotte, Isabelle; Vandenberg, Jamie I.

Afiliação

Ng CA; From the Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst and the St. Vincent's Clinical School, University of New South Wales, Victoria Street, Darlinghurst, New South Wales 2010, Australia and.
Gravel AE; the Department of Chemistry, Université du Québec à Montréal, Montreal H3C 3P8, Québec, Canada.
Perry MD; From the Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst and the St. Vincent's Clinical School, University of New South Wales, Victoria Street, Darlinghurst, New South Wales 2010, Australia and.
Arnold AA; the Department of Chemistry, Université du Québec à Montréal, Montreal H3C 3P8, Québec, Canada.
Marcotte I; the Department of Chemistry, Université du Québec à Montréal, Montreal H3C 3P8, Québec, Canada marcotte.isabelle@uqam.ca.
Vandenberg JI; From the Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst and the St. Vincent's Clinical School, University of New South Wales, Victoria Street, Darlinghurst, New South Wales 2010, Australia and j.vandenberg@victorchang.edu.au.

J Biol Chem ; 291(33): 17293-302, 2016 08 12.

Article em En | MEDLINE | ID: mdl-27317659

Assuntos

Membrana Celular/química; Canal de Potássio ERG1/química; Ativação do Canal Iônico/fisiologia; Peptídeos/química; Animais; Membrana Celular/genética; Membrana Celular/metabolismo; Canal de Potássio ERG1/genética; Canal de Potássio ERG1/metabolismo; Feminino; Humanos; Ressonância Magnética Nuclear Biomolecular; Peptídeos/genética; Peptídeos/metabolismo; Xenopus

Palavras-chave

Kv11.1; S4S5 linker; electrophysiology; gating; hERG; ion channel; lipid membrane; nuclear magnetic resonance (NMR); potassium channel; site-directed mutagenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Ativação do Canal Iônico / Membrana Celular / Canal de Potássio ERG1 Limite: Animals / Female / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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