Palladium-catalyzed ß-(hetero)arylation of &#945;,ß-unsaturated valerolactams.

Canterbury, Daniel P; Hesp, Kevin D; Polivkova, Jana

Palladium-catalyzed ß-(hetero)arylation of α,ß-unsaturated valerolactams.

Canterbury, Daniel P; Hesp, Kevin D; Polivkova, Jana.

Afiliação

Canterbury DP; Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, USA. daniel.canterbury@pfizer.com.
Hesp KD; Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, USA. daniel.canterbury@pfizer.com.
Polivkova J; Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, USA. daniel.canterbury@pfizer.com.

Org Biomol Chem ; 14(32): 7731-4, 2016 Aug 10.

Article em En | MEDLINE | ID: mdl-27461759

ABSTRACT

ABSTRACT

A method for the palladium-catalyzed arylation of α,ß-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described.

Assuntos

Hidrocarbonetos Bromados/síntese química; Lactamas/química; Paládio/química; Catálise; Hidrocarbonetos Bromados/química; Estrutura Molecular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Hidrocarbonetos Bromados / Lactamas Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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