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Prolonged Ocular Retention of Mucoadhesive Nanoparticle Eye Drop Formulation Enables Treatment of Eye Diseases Using Significantly Reduced Dosage.
Liu, Shengyan; Dozois, Matthew D; Chang, Chu Ning; Ahmad, Aaminah; Ng, Deborah L T; Hileeto, Denise; Liang, Huiyuan; Reyad, Matthew-Mina; Boyd, Shelley; Jones, Lyndon W; Gu, Frank X.
Afiliação
  • Liu S; Department of Chemical Engineering, University of Waterloo , Waterloo, Canada.
  • Dozois MD; Waterloo Institute of Nanotechnology, University of Waterloo , Waterloo, Canada.
  • Chang CN; Department of Chemical Engineering, University of Waterloo , Waterloo, Canada.
  • Ahmad A; Waterloo Institute of Nanotechnology, University of Waterloo , Waterloo, Canada.
  • Ng DL; Department of Chemical Engineering, University of Waterloo , Waterloo, Canada.
  • Hileeto D; Waterloo Institute of Nanotechnology, University of Waterloo , Waterloo, Canada.
  • Liang H; Department of Chemical Engineering, University of Waterloo , Waterloo, Canada.
  • Reyad MM; Waterloo Institute of Nanotechnology, University of Waterloo , Waterloo, Canada.
  • Boyd S; Department of Chemical Engineering, University of Waterloo , Waterloo, Canada.
  • Jones LW; Waterloo Institute of Nanotechnology, University of Waterloo , Waterloo, Canada.
  • Gu FX; Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo , Waterloo, Canada.
Mol Pharm ; 13(9): 2897-905, 2016 09 06.
Article em En | MEDLINE | ID: mdl-27482595
ABSTRACT
Eye diseases, such as dry eye syndrome, are commonly treated with eye drop formulations. However, eye drop formulations require frequent dosing with high drug concentrations due to poor ocular surface retention, which leads to poor patient compliance and high risks of side effects. We developed a mucoadhesive nanoparticle eye drop delivery platform to prolong the ocular retention of topical drugs, thus enabling treatment of eye diseases using reduced dosage. Using fluorescent imaging on rabbit eyes, we showed ocular retention of the fluorescent dye delivered through these nanoparticles beyond 24 h while free dyes were mostly cleared from the ocular surface within 3 h after administration. Utilizing the prolonged retention of the nanoparticles, we demonstrated effective treatment of experimentally induced dry eye in mice by delivering cyclosporin A (CsA) bound to this delivery system. The once a week dosing of 0.005 to 0.01% CsA in NP eye drop formulation demonstrated both the elimination of the inflammation signs and the recovery of ocular surface goblet cells after a month. Thrice daily administration of RESTASIS on mice only showed elimination without recovering the ocular surface goblet cells. The mucoadhesive nanoparticle eye drop platform demonstrated prolonged ocular surface retention and effective treatment of dry eye conditions with up to 50- to 100-fold reduction in overall dosage of CsA compared to RESTASIS, which may significantly reduce side effects and, by extending the interdosing interval, improve patient compliance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes do Olho Seco / Oftalmopatias / Nanopartículas Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes do Olho Seco / Oftalmopatias / Nanopartículas Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá