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Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Exell, Jack C; Thompson, Mark J; Finger, L David; Shaw, Steven J; Debreczeni, Judit; Ward, Thomas A; McWhirter, Claire; Siöberg, Catrine L B; Martinez Molina, Daniel; Abbott, W Mark; Jones, Clifford D; Nissink, J Willem M; Durant, Stephen T; Grasby, Jane A.
Afiliação
  • Exell JC; Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield, UK.
  • Thompson MJ; Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield, UK.
  • Finger LD; Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield, UK.
  • Shaw SJ; Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield, UK.
  • Debreczeni J; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK.
  • Ward TA; Bioscience, Oncology Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, Cheshire, UK.
  • McWhirter C; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK.
  • Siöberg CL; Pelago Bioscience AB, Solna, Sweden.
  • Martinez Molina D; Pelago Bioscience AB, Solna, Sweden.
  • Abbott WM; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK.
  • Jones CD; Chemistry, Oncology Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, UK.
  • Nissink JW; Chemistry, Oncology Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK.
  • Durant ST; Bioscience, Oncology Innovative Medicines and Early Development Biotech Unit, Cambridge, UK.
  • Grasby JA; Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield, UK.
Nat Chem Biol ; 12(10): 815-21, 2016 10.
Article em En | MEDLINE | ID: mdl-27526030
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endonucleases Flap / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endonucleases Flap / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido