Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita.

Woo, Dong-Hun; Chen, Qijun; Yang, Ting-Lin B; Glineburg, M Rebecca; Hoge, Carla; Leu, Nicolae A; Johnson, F Brad; Lengner, Christopher J

Woo, Dong-Hun; Chen, Qijun; Yang, Ting-Lin B; Glineburg, M Rebecca; Hoge, Carla; Leu, Nicolae A; Johnson, F Brad; Lengner, Christopher J.

Afiliação

Woo DH; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Chen Q; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yang TL; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Program, University of Pennsylvania, Philadelphia, PA 19104, USA.
Glineburg MR; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Program, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hoge C; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Vagelos Scholars Program, University of Pennsylvania, Philadelphia, PA 19104, USA.
Leu NA; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Johnson FB; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Program, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute on Aging, University of Pennsylvania, Philadelphia, PA 19104,
Lengner CJ; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Program, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, Universit

Cell Stem Cell ; 19(3): 397-405, 2016 09 01.

Article em En | MEDLINE | ID: mdl-27545506

Assuntos

Disceratose Congênita/patologia; Retroalimentação Fisiológica; Intestinos/citologia; Modelos Biológicos; Organoides/metabolismo; Células-Tronco/metabolismo; Telômero/metabolismo; Via de Sinalização Wnt; Animais; Sequência de Bases; Diferenciação Celular/efeitos dos fármacos; Disceratose Congênita/metabolismo; Retroalimentação Fisiológica/efeitos dos fármacos; Células HEK293; Humanos; Lítio/farmacologia; Camundongos; Organoides/efeitos dos fármacos; Fenótipo; Células-Tronco/efeitos dos fármacos; Proteína 2 de Ligação a Repetições Teloméricas/metabolismo; Via de Sinalização Wnt/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Organoides / Telômero / Disceratose Congênita / Retroalimentação Fisiológica / Via de Sinalização Wnt / Intestinos / Modelos Biológicos Limite: Animals / Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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