Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates.

Russell, Claire L; Mitra, Vikram; Hansson, Karl; Blennow, Kaj; Gobom, Johan; Zetterberg, Henrik; Hiltunen, Mikko; Ward, Malcolm; Pike, Ian

Russell, Claire L; Mitra, Vikram; Hansson, Karl; Blennow, Kaj; Gobom, Johan; Zetterberg, Henrik; Hiltunen, Mikko; Ward, Malcolm; Pike, Ian.

Afiliação

Russell CL; Proteome Sciences plc, South Wing Laboratory, Institute of Psychiatry, De Crespigny Park, London, UK.
Mitra V; Proteome Sciences plc, South Wing Laboratory, Institute of Psychiatry, De Crespigny Park, London, UK.
Hansson K; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Blennow K; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Gobom J; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Zetterberg H; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Hiltunen M; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Ward M; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Pike I; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

J Alzheimers Dis ; 55(1): 303-313, 2017.

Article em En | MEDLINE | ID: mdl-27636850

Assuntos

Doença de Alzheimer/líquido cefalorraquidiano; Espectrometria de Massas; Proteínas tau/líquido cefalorraquidiano; Peptídeos beta-Amiloides/líquido cefalorraquidiano; Biomarcadores/líquido cefalorraquidiano; Química Encefálica; Estudos de Coortes; Ensaio de Imunoadsorção Enzimática; Humanos; Fragmentos de Peptídeos/líquido cefalorraquidiano; Fosforilação; Proteínas tau/química

Palavras-chave

Alzheimer's disease; biomarkers; cerebrospinal fluid; mass spectrometry; neurodegenerative disease; phosphorylation; post translational modifications; tau

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Proteínas tau / Doença de Alzheimer Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido

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