Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells.

Miao, Chun-Mu; Jiang, Xiao-Wei; He, Kun; Li, Pei-Zhi; Liu, Zuo-Jin; Cao, Ding; Ou, Zhi-Bing; Gong, Jian-Ping; Liu, Chang-An; Cheng, Yao

Miao, Chun-Mu; Jiang, Xiao-Wei; He, Kun; Li, Pei-Zhi; Liu, Zuo-Jin; Cao, Ding; Ou, Zhi-Bing; Gong, Jian-Ping; Liu, Chang-An; Cheng, Yao.

Afiliação

Miao CM; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiang XW; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
He K; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li PZ; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu ZJ; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cao D; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ou ZB; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Gong JP; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu CA; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: liuchangan120@163.com.
Cheng Y; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: 124139153@QQ.com.

Immunol Lett ; 179: 102-113, 2016 11.

Article em En | MEDLINE | ID: mdl-27666012

Assuntos

Dinoprostona/metabolismo; Inflamassomos/metabolismo; Células de Kupffer/metabolismo; Lipopolissacarídeos/imunologia; Hepatopatias/etiologia; Hepatopatias/metabolismo; Células-Tronco Mesenquimais/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Doença Aguda; Animais; Apoptose; Biomarcadores; Biópsia; Caspase 1/metabolismo; Técnicas de Cocultura; Citocinas/metabolismo; Modelos Animais de Doenças; Lipopolissacarídeos/efeitos adversos; Hepatopatias/patologia; Masculino; Camundongos

Palavras-chave

Acute liver injury; BMSCs; Kupffer cells; NLRP3; PGE2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dinoprostona / Lipopolissacarídeos / Inflamassomos / Células-Tronco Mesenquimais / Proteína 3 que Contém Domínio de Pirina da Família NLR / Células de Kupffer / Hepatopatias Limite: Animals Idioma: En Revista: Immunol Lett Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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