Synthesis, structural studies, and cytotoxic evaluation of novel ursolic acid hybrids with capabilities to arrest breast cancer cells in mitosis.

Pattnaik, Banita; Lakshmi, Jerripothula K; Kavitha, Rachineni; Jagadeesh, Bharatam; Bhattacharjee, Debanjan; Jain, Nishant; Mallavadhani, Uppuluri V

Pattnaik, Banita; Lakshmi, Jerripothula K; Kavitha, Rachineni; Jagadeesh, Bharatam; Bhattacharjee, Debanjan; Jain, Nishant; Mallavadhani, Uppuluri V.

Afiliação

Pattnaik B; a Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Lakshmi JK; b NMR & Structural Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Kavitha R; b NMR & Structural Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Jagadeesh B; b NMR & Structural Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Bhattacharjee D; c Chemical Biology Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Jain N; c Chemical Biology Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Mallavadhani UV; a Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.

J Asian Nat Prod Res ; 19(3): 260-271, 2017 Mar.

Article em En | MEDLINE | ID: mdl-27762142

Assuntos

Triazóis/isolamento & purificação; Triterpenos; Ciclo Celular/efeitos dos fármacos; Química Click; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Humanos; Mitose/efeitos dos fármacos; Estrutura Molecular; Ressonância Magnética Nuclear Biomolecular; Triterpenos Pentacíclicos; Triazóis/química; Triazóis/farmacologia; Triterpenos/análise; Triterpenos/síntese química; Triterpenos/química; Triterpenos/farmacologia; Ácido Betulínico; Ácido Ursólico

Palavras-chave

2D NMR; Click chemistry; Ursolic acid; cytotoxicity; triazoles

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Triterpenos Limite: Female / Humans Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia

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