O-GlcNAcylation of 8-Oxoguanine DNA Glycosylase (Ogg1) Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts.

Cividini, Federico; Scott, Brian T; Dai, Anzhi; Han, Wenlong; Suarez, Jorge; Diaz-Juarez, Julieta; Diemer, Tanja; Casteel, Darren E; Dillmann, Wolfgang H

Cividini, Federico; Scott, Brian T; Dai, Anzhi; Han, Wenlong; Suarez, Jorge; Diaz-Juarez, Julieta; Diemer, Tanja; Casteel, Darren E; Dillmann, Wolfgang H.

Afiliação

Cividini F; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and fcividini@ucsd.edu.
Scott BT; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and.
Dai A; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and.
Han W; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and.
Suarez J; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and.
Diaz-Juarez J; the Department of Pharmacology, Instituto Nacional de Cardiología, Juan Badiano 41, Barrio Belisario Domínguez Secc XVI, 14080 Tlalpan, DF, Mexico.
Diemer T; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and.
Casteel DE; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and.
Dillmann WH; From the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0671 and wdillmann@ucsd.edu.

J Biol Chem ; 291(51): 26515-26528, 2016 Dec 16.

Article em En | MEDLINE | ID: mdl-27816939

Assuntos

Dano ao DNA; DNA Glicosilases/metabolismo; DNA Mitocondrial/metabolismo; Diabetes Mellitus Experimental/metabolismo; Cardiomiopatias Diabéticas/metabolismo; Mitocôndrias Cardíacas/metabolismo; Miócitos Cardíacos/metabolismo; Substituição de Aminoácidos; Animais; DNA Glicosilases/genética; DNA Mitocondrial/genética; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/patologia; Cardiomiopatias Diabéticas/genética; Cardiomiopatias Diabéticas/patologia; Hiperglicemia/genética; Hiperglicemia/metabolismo; Hiperglicemia/patologia; Masculino; Camundongos; Mitocôndrias Cardíacas/genética; Mutação de Sentido Incorreto

Palavras-chave

8-oxoguanine glycosylase (OGG1); cardiomyopathy; mtDNA; O-linked N-acetylglucosamine (O-GlcNAc); oxidative stress; type 1 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / DNA Mitocondrial / Miócitos Cardíacos / DNA Glicosilases / Diabetes Mellitus Experimental / Cardiomiopatias Diabéticas / Mitocôndrias Cardíacas Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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