Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions: A double blinded crossover study.
Med Oral Patol Oral Cir Bucal
; 22(1): e122-e131, 2017 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-27918744
ABSTRACT
BACKGROUND:
Using a double-blinded randomized crossover design, this study aimed to evaluate acute postoperative pain management, swelling and trismus in 46 volunteers undergoing extractions of the two lower third molars, in similar positions, at two different appointments who consumed a tablet of either NE (naproxen 500 mg + esomepraz ole 20 mg) or only naproxen (500 mg) every 12 hours for 4 days. MATERIAL ANDMETHODS:
Parameters were analyzed self-reported pain intensity using a visual analog scale (VAS) pre- and postoperative mouth opening; incidence, type and severity of adverse reactions; total quantity consumed of rescue medication; and pre- and postoperative swelling.RESULTS:
Female volunteers reported significantly more postoperative pain at 1, 1.5, 2, 3 and 4hrs after surgery while also taking their first rescue medication at a time significantly earlier when consuming NE when compared to naproxen (3.7hrs and 6.7hrs). Conversely, no differences were found between each drug group in males.CONCLUSIONS:
In conclusion, throughout the entire study, pain was mild after using either drug in both men and women with pain scores on average well below 40mm (VAS), although in women naproxen improved acute postoperative pain management when compared to NE.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Pós-Operatória
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Extração Dentária
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Anti-Inflamatórios não Esteroides
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Naproxeno
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Inibidores da Bomba de Prótons
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Manejo da Dor
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Esomeprazol
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Inflamação
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Dente Serotino
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Med Oral Patol Oral Cir Bucal
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article