A comparative assessment of cytotoxicity of commonly used agricultural insecticides to human and insect cells.
Ecotoxicol Environ Saf
; 137: 179-185, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-27940132
ABSTRACT
The cytotoxic potential of 13 commonly used agricultural insecticides was examined using cell-based systems with three human HepG2, Hek293, HeLa cells and three insect Tn5B1-4, Sf-21, and Drosophila S2 cells. Data showed that (1) an enhancement of some insecticides (e.g. pyrethroids) on cells proliferation; (2) an inhibition of some insecticides on cells viability; (3) various levels of susceptibility of different cells to the same insecticide; and (4) the cell type dependent sensitivity to different insecticides. The degree of cytotoxicity of insecticides on human cells was significantly lower than that on insect cells (P<0.05). Methomyl, even 20µg/ml, showed little cytotoxicity at 24h exposure whereas emamectin benzoate possessed the strongest cytotoxic potential in a dose-dependent fashion. The results revealed comparable cytotoxic property of agricultural insecticides against intact cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citotoxinas
/
Inseticidas
/
Insetos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Ecotoxicol Environ Saf
Ano de publicação:
2017
Tipo de documento:
Article