Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes.

Cheng, De; Zhao, Yuanjun; Wang, Shuwen; Zhang, Fan; Russo, Mariano; McMahon, Steven B; Zhu, Jiyue

Cheng, De; Zhao, Yuanjun; Wang, Shuwen; Zhang, Fan; Russo, Mariano; McMahon, Steven B; Zhu, Jiyue.

Afiliação

Cheng; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington, USA.
Zhao Y; Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA; and.
Wang S; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington, USA.
Zhang F; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington, USA.
Russo M; Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA; and.
McMahon SB; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Zhu J; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington, USA; jiyue.zhu@wsu.edu.

FASEB J ; 31(3): 1165-1178, 2017 03.

Article em En | MEDLINE | ID: mdl-27940549

Assuntos

Genoma Humano; Histona Desacetilase 1/metabolismo; Regiões Promotoras Genéticas; Telomerase/genética; Animais; Montagem e Desmontagem da Cromatina; Cromossomos Artificiais Bacterianos/genética; Células HEK293; Histona Desacetilase 1/genética; Humanos; Células MCF-7; Camundongos; Especificidade da Espécie; Telomerase/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Regiões Promotoras Genéticas / Telomerase / Histona Desacetilase 1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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