Imidazopyridyl compounds as aldosterone synthase inhibitors.

Whitehead, Brent R; Lo, Michael M-C; Ali, Amjad; Park, Min K; Hoyt, Scott B; Xiong, Yusheng; Cai, Jiaqiang; Carswell, Emma; Cooke, Andrew; MacLean, John; Ratcliffe, Paul; Robinson, John; Bennett, D Jonathan; Clemas, Joseph A; Wisniewski, Tom; Struthers, Mary; Cully, Doris; MacNeil, Douglas J

Whitehead, Brent R; Lo, Michael M-C; Ali, Amjad; Park, Min K; Hoyt, Scott B; Xiong, Yusheng; Cai, Jiaqiang; Carswell, Emma; Cooke, Andrew; MacLean, John; Ratcliffe, Paul; Robinson, John; Bennett, D Jonathan; Clemas, Joseph A; Wisniewski, Tom; Struthers, Mary; Cully, Doris; MacNeil, Douglas J.

Afiliação

Whitehead BR; MRL, Rahway, NJ 07065, USA. Electronic address: brent.whitehead@merck.com.
Lo MM; MRL, Rahway, NJ 07065, USA.
Ali A; MRL, Rahway, NJ 07065, USA.
Park MK; MRL, Rahway, NJ 07065, USA.
Hoyt SB; MRL, Rahway, NJ 07065, USA.
Xiong Y; MRL, Rahway, NJ 07065, USA.
Cai J; MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
Carswell E; MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
Cooke A; MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
MacLean J; MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
Ratcliffe P; MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
Robinson J; MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
Bennett DJ; MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
Clemas JA; MRL, Rahway, NJ 07065, USA.
Wisniewski T; MRL, Rahway, NJ 07065, USA.
Struthers M; MRL, Rahway, NJ 07065, USA.
Cully D; MRL, Rahway, NJ 07065, USA.
MacNeil DJ; MRL, Rahway, NJ 07065, USA.

Bioorg Med Chem Lett ; 27(2): 143-146, 2017 01 15.

Article em En | MEDLINE | ID: mdl-27979595

Assuntos

Citocromo P-450 CYP11B2/antagonistas & inibidores; Imidazóis/farmacologia; Piridinas/farmacologia; Animais; Cricetulus; Humanos; Imidazóis/síntese química; Imidazóis/química; Imidazóis/farmacocinética; Macaca mulatta; Masculino; Microssomos Hepáticos/metabolismo; Piridinas/síntese química; Piridinas/química; Piridinas/farmacocinética; Ratos Wistar; Esteroide 11-beta-Hidroxilase/antagonistas & inibidores; Relação Estrutura-Atividade

Palavras-chave

Aldosterone; CYP11B2; Heart failure; Hypertension; Imidazopyridine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Citocromo P-450 CYP11B2 / Imidazóis Limite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article

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