Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.

Fourati, Zaineb; Ruza, Reinis Reinholds; Laverty, Duncan; Drège, Emmanuelle; Delarue-Cochin, Sandrine; Joseph, Delphine; Koehl, Patrice; Smart, Trevor; Delarue, Marc

Fourati, Zaineb; Ruza, Reinis Reinholds; Laverty, Duncan; Drège, Emmanuelle; Delarue-Cochin, Sandrine; Joseph, Delphine; Koehl, Patrice; Smart, Trevor; Delarue, Marc.

Afiliação

Fourati Z; From the Unité de Dynamique Structurale des Macromolécules, UMR 3528 du CNRS, Institut Pasteur, 75015 Paris, France.
Ruza RR; From the Unité de Dynamique Structurale des Macromolécules, UMR 3528 du CNRS, Institut Pasteur, 75015 Paris, France.
Laverty D; the Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Drège E; the UMR 8076 du CNRS, BioCIS, Faculté de Pharmacie, Université Paris Sud, 92296 Chatenay-Malabry, France.
Delarue-Cochin S; the UMR 8076 du CNRS, BioCIS, Faculté de Pharmacie, Université Paris Sud, 92296 Chatenay-Malabry, France.
Joseph D; the UMR 8076 du CNRS, BioCIS, Faculté de Pharmacie, Université Paris Sud, 92296 Chatenay-Malabry, France.
Koehl P; the Department of Computer Science, University of California, Davis, California 95616.
Smart T; the Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom. Electronic address: t.smart@ucl.ac.uk.
Delarue M; From the Unité de Dynamique Structurale des Macromolécules, UMR 3528 du CNRS, Institut Pasteur, 75015 Paris, France. Electronic address: delarue@pasteur.fr.

J Biol Chem ; 292(5): 1550-1558, 2017 02 03.

Article em En | MEDLINE | ID: mdl-27986812

Assuntos

Proteínas de Bactérias/química; Barbitúricos/química; Canais Iônicos/química; Modelos Moleculares; Animais; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Barbitúricos/farmacologia; Sítios de Ligação; Cristalografia por Raios X; Cianobactérias; Canais Iônicos/genética; Canais Iônicos/metabolismo; Estrutura Quaternária de Proteína; Xenopus laevis

Palavras-chave

anesthesia; barbiturates; crystallography; electrophysiology; ligand-gated ion channels; membrane protein; structural biology; x-ray crystallography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Barbitúricos / Modelos Moleculares / Canais Iônicos Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França

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