Notochordal cell-derived conditioned medium protects human nucleus pulposus cells from stress-induced apoptosis.

Mehrkens, Arne; Matta, Ajay; Karim, Muhammad Zia; Kim, Sarah; Fehlings, Michael G; Schaeren, Stefan; Mark Erwin, William

Mehrkens, Arne; Matta, Ajay; Karim, Muhammad Zia; Kim, Sarah; Fehlings, Michael G; Schaeren, Stefan; Mark Erwin, William.

Afiliação

Mehrkens A; Krembil Research Institute, Toronto Western Hospital, 60 Leonard Ave, Toronto, Ontario M5T 2S8, Canada; Spine Surgery, University Hospital Basel, Spitalstr. 21, CH-4031 Basel, Switzerland.
Matta A; Krembil Research Institute, Toronto Western Hospital, 60 Leonard Ave, Toronto, Ontario M5T 2S8, Canada.
Karim MZ; Krembil Research Institute, Toronto Western Hospital, 60 Leonard Ave, Toronto, Ontario M5T 2S8, Canada.
Kim S; Krembil Research Institute, Toronto Western Hospital, 60 Leonard Ave, Toronto, Ontario M5T 2S8, Canada.
Fehlings MG; Krembil Research Institute, Toronto Western Hospital, 60 Leonard Ave, Toronto, Ontario M5T 2S8, Canada; Division of Neurosurgery and Spine Program, University of Toronto, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario M5T 2S8, Canada.
Schaeren S; Spine Surgery, University Hospital Basel, Spitalstr. 21, CH-4031 Basel, Switzerland.
Mark Erwin W; Krembil Research Institute, Toronto Western Hospital, 60 Leonard Ave, Toronto, Ontario M5T 2S8, Canada; Division of Neurosurgery and Spine Program, University of Toronto, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario M5T 2S8, Canada; Division of Orthopaedic Surgery, University of Toron

Spine J ; 17(4): 579-588, 2017 04.

Article em En | MEDLINE | ID: mdl-28089818

Assuntos

Apoptose; Notocorda/metabolismo; Núcleo Pulposo/citologia; Células Cultivadas; Meios de Cultivo Condicionados/farmacologia; Proteína Ligante Fas/metabolismo; Humanos; Interleucina-6/metabolismo; Interleucina-8/metabolismo; Notocorda/citologia; Núcleo Pulposo/efeitos dos fármacos; Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X/metabolismo

Palavras-chave

Apoptosis; Cell proliferation; Cytokines; Degenerative disc disease; Human nucleus pulposus; Notochordal cell; X-linked inhibitor of apoptotic proteins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Núcleo Pulposo / Notocorda Limite: Humans Idioma: En Revista: Spine J Assunto da revista: ORTOPEDIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suíça

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