Inhibition of NF-&#954;B Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy.

Liu, Pi Chu; Lu, Gang; Deng, Yi; Wang, Cheng Dong; Su, Xian Wei; Zhou, Jing Ye; Chan, Tat Ming; Hu, Xiang; Poon, Wai Sang

Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy.

Liu, Pi Chu; Lu, Gang; Deng, Yi; Wang, Cheng Dong; Su, Xian Wei; Zhou, Jing Ye; Chan, Tat Ming; Hu, Xiang; Poon, Wai Sang.

Afiliação

Liu PC; Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Lu G; Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Deng Y; Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, China.
Wang CD; Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Su XW; Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Zhou JY; Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Chan TM; Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Hu X; Shenzhen Beike Cell Engineering Research Institute, Shenzhen, China.
Poon WS; Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.

PLoS One ; 12(1): e0171157, 2017.

Article em En | MEDLINE | ID: mdl-28135339

Assuntos

Glioblastoma/tratamento farmacológico; Glioblastoma/enzimologia; Lovastatina/uso terapêutico; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; NF-kappa B/metabolismo; Ligante Indutor de Apoptose Relacionado a TNF/uso terapêutico; Animais; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Modelos Animais de Doenças; Glioblastoma/patologia; Células HEK293; Humanos; Lovastatina/administração & dosagem; Lovastatina/farmacologia; Camundongos Endogâmicos BALB C; Camundongos Nus; Modelos Biológicos; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/metabolismo; Tela Subcutânea/efeitos dos fármacos; Tela Subcutânea/patologia; Ligante Indutor de Apoptose Relacionado a TNF/farmacologia; Regulação para Cima/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lovastatina / NF-kappa B / Glioblastoma / Sistema de Sinalização das MAP Quinases / Ligante Indutor de Apoptose Relacionado a TNF Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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