Plasma levels of cyclic nucleotides are elevated in atopic eczema.
Arch Dermatol Res
; 279 Suppl: S59-62, 1987.
Article
em En
| MEDLINE
| ID: mdl-2821928
ABSTRACT
Plasma cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) taken at distinct times of the day were measured in 45 inpatients with generalized atopic eczema (AE). The results were compared with 34 healthy controls. Female patients not taking oral contraceptives (OC) and male patients revealed significantly higher median levels of cAMP in comparison with the controls (p less than 0.002 for males; p less than 0.001 for females). No significant cAMP differences were found between patients of either sex and female controls taking OC. The median cGMP plasma levels did not differ between patients and controls. Both cyclic nucleotides are discussed under the aspect of cAMP as a second messenger of various hormones, reflecting and integrating different responses of the body to AE as a distressing systemic skin disorder.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
AMP Cíclico
/
GMP Cíclico
/
Dermatite Atópica
Limite:
Adolescent
/
Adult
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arch Dermatol Res
Ano de publicação:
1987
Tipo de documento:
Article