Dendrimer-reinforced sol-gel based hollow fiber solid-phase microextraction for citalopram determination using response surface methodology.
J Sep Sci
; 40(10): 2246-2252, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28323381
ABSTRACT
The inclusion of a polyamidoamine dendrimer in a silica sol-gel yielded a solid nanosorbent that was used for the preconcentration, extraction, and determination of citalopram in hospital waste water, hemodialysis solution, and some drinking water. The method was developed by applying a novel nanosorbent for the solid-phase microextraction of citalopram, containing a silica sol-gel reinforced by polyamidoamine second-generation dendrimer, which was protected by a polypropylene hollow fiber. Plackett-Burman design and central composite design were utilized to evaluate the significance of several factors on the extraction efficiency. The adsorption mechanism and thermodynamic and kinetic aspects were studied. The adsorption process was exothermic and well fitted to the Bangham equation kinetic model. Under optimal conditions, the presented method was liner in the range of 0.05-100 µg/mL. The limits of detection of quantification of citalopram were 0.0095 and 0.031 µg m/L, respectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citalopram
/
Dendrímeros
/
Microextração em Fase Sólida
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Sep Sci
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Irã