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Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.
Denny, R Aldrin; Flick, Andrew C; Coe, Jotham; Langille, Jonathan; Basak, Arindrajit; Liu, Shenping; Stock, Ingrid; Sahasrabudhe, Parag; Bonin, Paul; Hay, Duncan A; Brennan, Paul E; Pletcher, Mathew; Jones, Lyn H; Chekler, Eugene L Piatnitski.
Afiliação
  • Denny RA; Medicine Design, Pfizer , 610 Main Street, Cambridge Massachusetts 02139, United States.
  • Flick AC; Medicine Design, Pfizer , Eastern Point Road, Groton Connecticut 06340, United States.
  • Coe J; Medicine Design, Pfizer , Eastern Point Road, Groton Connecticut 06340, United States.
  • Basak A; Medicine Design, Pfizer , Eastern Point Road, Groton Connecticut 06340, United States.
  • Liu S; Structural Biology and Biophysics, Medicine Design, Pfizer , Eastern Point Road, Groton Connecticut 06340, United States.
  • Stock I; Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton Connecticut 06340, United States.
  • Sahasrabudhe P; Structural Biology and Biophysics, Medicine Design, Pfizer , Eastern Point Road, Groton Connecticut 06340, United States.
  • Bonin P; Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton Connecticut 06340, United States.
  • Hay DA; Evotec (UK) Ltd. , 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK.
  • Brennan PE; Structural Genomics Consortium, Target Discovery Institute, ARUK Oxford Drug Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Pletcher M; Structural Genomics Consortium, Target Discovery Institute, ARUK Oxford Drug Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Jones LH; Rare Disease Research Unit, Pfizer , 610 Main Street, Cambridge Massachusetts 02139, United States.
  • Chekler ELP; Medicine Design, Pfizer , 610 Main Street, Cambridge Massachusetts 02139, United States.
J Med Chem ; 60(13): 5349-5363, 2017 07 13.
Article em En | MEDLINE | ID: mdl-28375629
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Morfolinas / Proteína de Ligação a CREB / Proteína p300 Associada a E1A Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Morfolinas / Proteína de Ligação a CREB / Proteína p300 Associada a E1A Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos