Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors.

Shaik, Siddiq Pasha; Vishnuvardhan, M V P S; Sultana, Faria; Subba Rao, A V; Bagul, Chandrakant; Bhattacharjee, Debanjan; Kapure, Jeevak Sopanrao; Jain, Nishant; Kamal, Ahmed

Shaik, Siddiq Pasha; Vishnuvardhan, M V P S; Sultana, Faria; Subba Rao, A V; Bagul, Chandrakant; Bhattacharjee, Debanjan; Kapure, Jeevak Sopanrao; Jain, Nishant; Kamal, Ahmed.

Afiliação

Shaik SP; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi 110 025, India.
Vishnuvardhan MVPS; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India.
Sultana F; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India.
Subba Rao AV; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi 110 025, India.
Bagul C; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500 037, India.
Bhattacharjee D; Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India.
Kapure JS; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500 037, India.
Jain N; Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India.
Kamal A; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi 110 025, India; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education & Research (NIPE

Bioorg Med Chem ; 25(13): 3285-3297, 2017 07 01.

Article em En | MEDLINE | ID: mdl-28462842

Assuntos

Antineoplásicos/farmacologia; Desenho de Fármacos; Imidazóis/farmacologia; Tiazóis/farmacologia; Triazóis/farmacologia; Tubulina (Proteína)/metabolismo; Antineoplásicos/síntese química; Antineoplásicos/química; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Imidazóis/química; Células MCF-7; Simulação de Acoplamento Molecular; Estrutura Molecular; Polimerização/efeitos dos fármacos; Relação Estrutura-Atividade; Tiazóis/química; Triazóis/química

Palavras-chave

1,2,3-Triazole; Apoptosis; Benzo[d]imidazo[2,1-b]thiazole; Cytotoxicity; Tubulin depolymerization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Triazóis / Tubulina (Proteína) / Desenho de Fármacos / Imidazóis / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia

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