Your browser doesn't support javascript.
loading
Genomic epidemiology reveals multiple introductions of Zika virus into the United States.
Grubaugh, Nathan D; Ladner, Jason T; Kraemer, Moritz U G; Dudas, Gytis; Tan, Amanda L; Gangavarapu, Karthik; Wiley, Michael R; White, Stephen; Thézé, Julien; Magnani, Diogo M; Prieto, Karla; Reyes, Daniel; Bingham, Andrea M; Paul, Lauren M; Robles-Sikisaka, Refugio; Oliveira, Glenn; Pronty, Darryl; Barcellona, Carolyn M; Metsky, Hayden C; Baniecki, Mary Lynn; Barnes, Kayla G; Chak, Bridget; Freije, Catherine A; Gladden-Young, Adrianne; Gnirke, Andreas; Luo, Cynthia; MacInnis, Bronwyn; Matranga, Christian B; Park, Daniel J; Qu, James; Schaffner, Stephen F; Tomkins-Tinch, Christopher; West, Kendra L; Winnicki, Sarah M; Wohl, Shirlee; Yozwiak, Nathan L; Quick, Joshua; Fauver, Joseph R; Khan, Kamran; Brent, Shannon E; Reiner, Robert C; Lichtenberger, Paola N; Ricciardi, Michael J; Bailey, Varian K; Watkins, David I; Cone, Marshall R; Kopp, Edgar W; Hogan, Kelly N; Cannons, Andrew C; Jean, Reynald.
Afiliação
  • Grubaugh ND; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Ladner JT; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
  • Kraemer MUG; Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.
  • Dudas G; Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Tan AL; Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Gangavarapu K; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Wiley MR; Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
  • White S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Thézé J; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
  • Magnani DM; College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
  • Prieto K; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, Florida 33125, USA.
  • Reyes D; Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.
  • Bingham AM; Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
  • Paul LM; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
  • Robles-Sikisaka R; College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
  • Oliveira G; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
  • Pronty D; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
  • Barcellona CM; Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida 32399, USA.
  • Metsky HC; Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
  • Baniecki ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Barnes KG; Scripps Translational Science Institute, La Jolla, California 92037, USA.
  • Chak B; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, Florida 33125, USA.
  • Freije CA; Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
  • Gladden-Young A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Gnirke A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Luo C; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • MacInnis B; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Matranga CB; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Park DJ; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Qu J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Schaffner SF; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Tomkins-Tinch C; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • West KL; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Winnicki SM; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Wohl S; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Yozwiak NL; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Quick J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Fauver JR; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Khan K; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Brent SE; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Reiner RC; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Lichtenberger PN; Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.
  • Ricciardi MJ; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA.
  • Bailey VK; Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario M5B 1T8, Canada.
  • Watkins DI; Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Cone MR; Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario M5B 1T8, Canada.
  • Kopp EW; Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington 98121, USA.
  • Hogan KN; Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
  • Cannons AC; Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
  • Jean R; Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Nature ; 546(7658): 401-405, 2017 06 15.
Article em En | MEDLINE | ID: mdl-28538723
ABSTRACT
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zika virus / Infecção por Zika virus Tipo de estudo: Incidence_studies / Prognostic_studies / Screening_studies Limite: Animals / Female / Humans País/Região como assunto: America do norte Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zika virus / Infecção por Zika virus Tipo de estudo: Incidence_studies / Prognostic_studies / Screening_studies Limite: Animals / Female / Humans País/Região como assunto: America do norte Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos