Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding.

Smith, Richard W P; Anderson, Ross C; Larralde, Osmany; Smith, Joel W S; Gorgoni, Barbara; Richardson, William A; Malik, Poonam; Graham, Sheila V; Gray, Nicola K

Smith, Richard W P; Anderson, Ross C; Larralde, Osmany; Smith, Joel W S; Gorgoni, Barbara; Richardson, William A; Malik, Poonam; Graham, Sheila V; Gray, Nicola K.

Afiliação

Smith RWP; Medical Research Council Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom; nicola.gray@ed.ac.uk r.smith@ed.ac.uk.
Anderson RC; Medical Research Council Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.
Larralde O; Medical Research Council-University of Glasgow Centre for Virus Research, Garscube Campus, Glasgow G61 1QH, United Kingdom.
Smith JWS; Medical Research Council Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
Gorgoni B; Medical Research Council Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.
Richardson WA; Medical Research Council-University of Glasgow Centre for Virus Research, Garscube Campus, Glasgow G61 1QH, United Kingdom.
Malik P; Medical Research Council Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.
Graham SV; Medical Research Council Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
Gray NK; Medical Research Council Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

Proc Natl Acad Sci U S A ; 114(24): 6310-6315, 2017 06 13.

Article em En | MEDLINE | ID: mdl-28559344

Assuntos

Fator de Iniciação Eucariótico 4G/metabolismo; Proteínas de Ligação a Poli(A)/metabolismo; RNA Mensageiro/metabolismo; Animais; Fator de Iniciação Eucariótico 4G/genética; Feminino; Proteínas Imediatamente Precoces/genética; Proteínas Imediatamente Precoces/metabolismo; Modelos Biológicos; Mutação; Oócitos/metabolismo; Iniciação Traducional da Cadeia Peptídica; Proteínas de Ligação a Poli(A)/genética; Ligação Proteica; Capuzes de RNA/genética; Capuzes de RNA/metabolismo; RNA Mensageiro/genética; RNA Viral/genética; RNA Viral/metabolismo; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Técnicas do Sistema de Duplo-Híbrido; Xenopus laevis

Palavras-chave

DAZL; ICP27; mRNA-binding protein; mRNA-specific translational regulation; poly(A)-binding protein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Proteínas de Ligação a Poli(A) / Fator de Iniciação Eucariótico 4G Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article

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