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Leukocyte telomere length and renal cell carcinoma survival in two studies.
Callahan, Catherine L; Schwartz, Kendra; Ruterbusch, Julie J; Shuch, Brian; Graubard, Barry I; Lan, Qing; Cawthon, Richard; Baccarelli, Andrea A; Chow, Wong-Ho; Rothman, Nathaniel; Hofmann, Jonathan N; Purdue, Mark P.
Afiliação
  • Callahan CL; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Rockville, MD 20850, USA.
  • Schwartz K; Department of Family Medicine and Public Health Sciences, Karmanos Cancer Institute, Wayne State University, 3939 Woodward Ave., Detroit, MI 48201, USA.
  • Ruterbusch JJ; Department of Family Medicine and Public Health Sciences, Karmanos Cancer Institute, Wayne State University, 3939 Woodward Ave., Detroit, MI 48201, USA.
  • Shuch B; Department of Urology, Yale School of Medicine, PO Box 208058, New Haven, CT 06520, USA.
  • Graubard BI; Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Rockville, MD 20850, USA.
  • Lan Q; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Rockville, MD 20850, USA.
  • Cawthon R; Department of Human Genetics, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA.
  • Baccarelli AA; Laboratory of Environmental Precision Biosciences, Mailman School of Public Health, Columbia University, 722 West 168th St., New York, NY 10032, USA.
  • Chow WH; Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Unit 1340 PO Box 301439, Houston, TX 77230-1439, USA.
  • Rothman N; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Rockville, MD 20850, USA.
  • Hofmann JN; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Rockville, MD 20850, USA.
  • Purdue MP; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Rockville, MD 20850, USA.
Br J Cancer ; 117(5): 752-755, 2017 Aug 22.
Article em En | MEDLINE | ID: mdl-28742796
BACKGROUND: Leukocyte telomere length (LTL) is a potential biomarker of cancer prognosis; however, evidence for renal cell carcinoma (RCC) is inconsistent. METHODS: We investigated LTL and RCC-specific survival among 684 cases from the US kidney cancer study (USKC) and 241 cases from the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO). Leukocyte telomere length was measured by quantitative polymerase chain reaction, and hazard ratios (HRs) and 95% confidence intervals (CIs) computed using multivariable Cox models. RESULTS: Short LTL was associated with poorer disease-specific survival in both USKC (lowest vs highest quartile: HR: 2.3, 95% CI: 1.2-4.4; P for trend=0.02) and PLCO (HR: 2.4, 95% CI: 1.0-5.4; P=0.04). Among USKC cases, the association was strongest for stage-I RCC (HR: 5.5, 95% CI: 1.6-19.0; P=0.006). CONCLUSIONS: Our findings suggest that shorter LTL is an independent marker of poor RCC prognosis, particularly for stage-I disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias da Próstata / Carcinoma de Células Renais / Neoplasias Colorretais / Telômero / Encurtamento do Telômero / Neoplasias Renais / Leucócitos / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias da Próstata / Carcinoma de Células Renais / Neoplasias Colorretais / Telômero / Encurtamento do Telômero / Neoplasias Renais / Leucócitos / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos