The relationship between alterations in alpha 1-adrenoceptor reserve by phenoxybenzamine and benextramine and the sensitivity of cirazoline-induced pressor responses to inhibition by nifedipine.
Eur J Pharmacol
; 126(3): 297-301, 1986 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-2875887
ABSTRACT
Nifedipine does not inhibit the alpha 1-adrenoceptor-mediated pressor response of cirazoline at a dose that significantly antagonizes the alpha 2-adrenoceptor-mediated pressor response of B-HT 933. After elimination of the alpha 1-adrenoceptor reserve with either phenoxybenzamine or benextramine, the response to cirazoline was rendered highly sensitive to antagonism by nifedipine. These results support the hypothesis that the resistance of alpha 1-adrenoceptor-mediated pressor responses to inhibition by calcium channel antagonists may be caused by a large alpha 1-adrenoceptor reserve.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nifedipino
/
Receptores Adrenérgicos alfa
/
Antagonistas Adrenérgicos alfa
/
Imidazóis
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1986
Tipo de documento:
Article