Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins.
Sci Rep
; 7(1): 9580, 2017 08 29.
Article
em En
| MEDLINE
| ID: mdl-28852021
ABSTRACT
Elongation factor eIF5A is required for the translation of consecutive prolines, and was shown in yeast to translate polyproline-containing Bni1, an actin-nucleating formin required for polarized growth during mating. Here we show that Drosophila eIF5A can functionally replace yeast eIF5A and is required for actin-rich cable assembly during embryonic dorsal closure (DC). Furthermore, Diaphanous, the formin involved in actin dynamics during DC, is regulated by and mediates eIF5A effects. Finally, eIF5A controls cell migration and regulates Diaphanous levels also in mammalian cells. Our results uncover an evolutionary conserved role of eIF5A regulating cytoskeleton-dependent processes through translation of formins in eukaryotes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Iniciação de Peptídeos
/
Proteínas de Ligação a RNA
/
Evolução Biológica
/
Proteínas dos Microfilamentos
Limite:
Animals
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha