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Intra and inter-session reliability of rapid Transcranial Magnetic Stimulation stimulus-response curves of tibialis anterior muscle in healthy older adults.
Peri, Elisabetta; Ambrosini, Emilia; Colombo, Vera Maria; van de Ruit, Mark; Grey, Michael J; Monticone, Marco; Ferriero, Giorgio; Pedrocchi, Alessandra; Ferrigno, Giancarlo; Ferrante, Simona.
Afiliação
  • Peri E; NearLab, Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
  • Ambrosini E; NearLab, Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
  • Colombo VM; Department of Physical and Rehabilitative Medicine, Scientific Institute of Lissone IRCCS, Istituti Clinici Scientifici Maugeri, Lissone, MB, Italy.
  • van de Ruit M; NearLab, Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
  • Grey MJ; Department of Biomechanical Engineering Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands.
  • Monticone M; Acquired Brain Injury Rehabilitation Alliance, School of Health Sciences, University of East Anglia, Norwich, United Kingdom.
  • Ferriero G; Department of Physical and Rehabilitative Medicine, Scientific Institute of Lissone IRCCS, Istituti Clinici Scientifici Maugeri, Lissone, MB, Italy.
  • Pedrocchi A; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
  • Ferrigno G; Department of Physical and Rehabilitative Medicine, Scientific Institute of Lissone IRCCS, Istituti Clinici Scientifici Maugeri, Lissone, MB, Italy.
  • Ferrante S; NearLab, Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
PLoS One ; 12(9): e0184828, 2017.
Article em En | MEDLINE | ID: mdl-28910370
OBJECTIVE: The clinical use of Transcranial Magnetic Stimulation (TMS) as a technique to assess corticospinal excitability is limited by the time for data acquisition and the measurement variability. This study aimed at evaluating the reliability of Stimulus-Response (SR) curves acquired with a recently proposed rapid protocol on tibialis anterior muscle of healthy older adults. METHODS: Twenty-four neurologically-intact adults (age:55-75 years) were recruited for this test-retest study. During each session, six SR curves, 3 at rest and 3 during isometric muscle contractions at 5% of maximum voluntary contraction (MVC), were acquired. Motor Evoked Potentials (MEPs) were normalized to the maximum peripherally evoked response; the coil position and orientation were monitored with an optical tracking system. Intra- and inter-session reliability of motor threshold (MT), area under the curve (AURC), MEPmax, stimulation intensity at which the MEP is mid-way between MEPmax and MEPmin (I50), slope in I50, MEP latency, and silent period (SP) were assessed in terms of Standard Error of Measurement (SEM), relative SEM, Minimum Detectable Change (MDC), and Intraclass Correlation Coefficient (ICC). RESULTS: The relative SEM was ≤10% for MT, I50, latency and SP both at rest and 5%MVC, while it ranged between 11% and 37% for AURC, MEPmax, and slope. MDC values were overall quite large; e.g., MT required a change of 12%MSO at rest and 10%MSO at 5%MVC to be considered a real change. Inter-sessions ICC were >0.6 for all measures but slope at rest and MEPmax and latency at 5%MVC. CONCLUSIONS: Measures derived from SR curves acquired in <4 minutes are affected by similar measurement errors to those found with long-lasting protocols, suggesting that the rapid method is at least as reliable as the traditional methods. As specifically designed to include older adults, this study provides normative data for future studies involving older neurological patients (e.g. stroke survivors).
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Músculo Esquelético / Estimulação Magnética Transcraniana Tipo de estudo: Guideline / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Músculo Esquelético / Estimulação Magnética Transcraniana Tipo de estudo: Guideline / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália