Transcription factor YY1 can control AID-mediated mutagenesis in mice.

Zaprazna, Kristina; Basu, Arindam; Tom, Nikola; Jha, Vibha; Hodawadekar, Suchita; Radova, Lenka; Malcikova, Jitka; Tichy, Boris; Pospisilova, Sarka; Atchison, Michael L

Zaprazna, Kristina; Basu, Arindam; Tom, Nikola; Jha, Vibha; Hodawadekar, Suchita; Radova, Lenka; Malcikova, Jitka; Tichy, Boris; Pospisilova, Sarka; Atchison, Michael L.

Afiliação

Zaprazna K; Central European Institute of Technology, Masaryk University, Centre of Molecular Medicine, Brno, Czech Republic.
Basu A; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
Tom N; Central European Institute of Technology, Masaryk University, Centre of Molecular Medicine, Brno, Czech Republic.
Jha V; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
Hodawadekar S; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
Radova L; Central European Institute of Technology, Masaryk University, Centre of Molecular Medicine, Brno, Czech Republic.
Malcikova J; Central European Institute of Technology, Masaryk University, Centre of Molecular Medicine, Brno, Czech Republic.
Tichy B; Central European Institute of Technology, Masaryk University, Centre of Molecular Medicine, Brno, Czech Republic.
Pospisilova S; Central European Institute of Technology, Masaryk University, Centre of Molecular Medicine, Brno, Czech Republic.
Atchison ML; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.

Eur J Immunol ; 48(2): 273-282, 2018 02.

Article em En | MEDLINE | ID: mdl-29080214

Assuntos

Linfócitos B/fisiologia; Mutagênese/genética; Fator de Transcrição YY1/genética; Animais; Citidina Desaminase/metabolismo; Quebras de DNA de Cadeia Dupla; Feminino; Switching de Imunoglobulina/genética; Ativação Linfocitária; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Mutação/genética; Ligação Proteica; Hipermutação Somática de Imunoglobulina/genética; Ubiquitinação

Palavras-chave

AID; YY1; class switch recombination; somatic hypermutation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Mutagênese / Fator de Transcrição YY1 Limite: Animals Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: República Tcheca

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