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Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.
Jasinska, Anna J; Zelaya, Ivette; Service, Susan K; Peterson, Christine B; Cantor, Rita M; Choi, Oi-Wa; DeYoung, Joseph; Eskin, Eleazar; Fairbanks, Lynn A; Fears, Scott; Furterer, Allison E; Huang, Yu S; Ramensky, Vasily; Schmitt, Christopher A; Svardal, Hannes; Jorgensen, Matthew J; Kaplan, Jay R; Villar, Diego; Aken, Bronwen L; Flicek, Paul; Nag, Rishi; Wong, Emily S; Blangero, John; Dyer, Thomas D; Bogomolov, Marina; Benjamini, Yoav; Weinstock, George M; Dewar, Ken; Sabatti, Chiara; Wilson, Richard K; Jentsch, J David; Warren, Wesley; Coppola, Giovanni; Woods, Roger P; Freimer, Nelson B.
Afiliação
  • Jasinska AJ; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Zelaya I; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
  • Service SK; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, California, USA.
  • Peterson CB; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Cantor RM; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Choi OW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • DeYoung J; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, USA.
  • Eskin E; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Fairbanks LA; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Fears S; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, USA.
  • Furterer AE; Department of Computer Science, University of California, Los Angeles, Los Angeles, California, USA.
  • Huang YS; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Ramensky V; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Schmitt CA; Interdepartmental Graduate Program in Neuroscience, University of California, Los Angeles, Los Angeles, California, USA.
  • Svardal H; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Jorgensen MJ; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Kaplan JR; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Villar D; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Aken BL; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Flicek P; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Nag R; University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK.
  • Wong ES; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Blangero J; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Dyer TD; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Bogomolov M; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Benjamini Y; South Texas Diabetes and Obesity Institute, UTHSCSA/UTRGV, Brownsville, Texas, USA.
  • Weinstock GM; South Texas Diabetes and Obesity Institute, UTHSCSA/UTRGV, Brownsville, Texas, USA.
  • Dewar K; Faculty of Industrial Engineering and Management, Technion, Haifa, Israel.
  • Sabatti C; Department of Statistics and Operation Research, Tel Aviv University, Tel Aviv, Israel.
  • Wilson RK; Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
  • Jentsch JD; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
  • Warren W; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Coppola G; Department of Statistics, Stanford University, Stanford, California, USA.
  • Woods RP; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Freimer NB; Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Nat Genet ; 49(12): 1714-1721, 2017 Dec.
Article em En | MEDLINE | ID: mdl-29083405
By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Chlorocebus aethiops / Perfilação da Expressão Gênica / Locos de Características Quantitativas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Chlorocebus aethiops / Perfilação da Expressão Gênica / Locos de Características Quantitativas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos