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Expressed fusion gene landscape and its impact in multiple myeloma.
Cleynen, A; Szalat, R; Kemal Samur, M; Robiou du Pont, S; Buisson, L; Boyle, E; Chretien, M L; Anderson, K; Minvielle, S; Moreau, P; Attal, M; Parmigiani, G; Corre, J; Munshi, N; Avet-Loiseau, H.
Afiliação
  • Cleynen A; Institut Montpellierain Alexander Grothendieck, CNRS, Univ. Montpellier, Montpellier, 34090, France.
  • Szalat R; Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Kemal Samur M; Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Robiou du Pont S; Department of Biostatistics and Computational Biology, Dana-Farber Cancer, Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Buisson L; IUC-Oncopole, and CRCT INSERM U1037, Toulouse, 31100, France.
  • Boyle E; IUC-Oncopole, and CRCT INSERM U1037, Toulouse, 31100, France.
  • Chretien ML; IUC-Oncopole, and CRCT INSERM U1037, Toulouse, 31100, France.
  • Anderson K; CHU Dijon, Dijon, 21000, France.
  • Minvielle S; Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Moreau P; CHU Nantes, Nantes, 44000, France.
  • Attal M; CHU Nantes, Nantes, 44000, France.
  • Parmigiani G; IUC-Oncopole, and CRCT INSERM U1037, Toulouse, 31100, France.
  • Corre J; Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Munshi N; Department of Biostatistics and Computational Biology, Dana-Farber Cancer, Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Avet-Loiseau H; IUC-Oncopole, and CRCT INSERM U1037, Toulouse, 31100, France.
Nat Commun ; 8(1): 1893, 2017 12 01.
Article em En | MEDLINE | ID: mdl-29196615
Multiple myeloma is a plasma cell malignancy characterized by recurrent IgH translocations and well described genomic heterogeneity. Although transcriptome profiles in multiple myeloma has been described, landscape of expressed fusion genes and their clinical impact remains unknown. To provide a comprehensive and detailed fusion gene cartography and suggest new mechanisms of tumorigenesis in multiple myeloma, we performed RNA sequencing in a cohort of 255 newly diagnosed and homogeneously treated multiple myeloma patients with long follow-up. Here, we report that patients have on average 5.5 expressed fusion genes. Kappa and lambda light chains and IgH genes are main partners in a third of all fusion genes. We also identify recurrent fusion genes that significantly impact both progression-free and overall survival and may act as drivers of the disease. Lastly, we find a correlation between the number of fusions, the age of patients and the clinical outcome, strongly suggesting that genomic instability drives prognosis of the disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fusão Gênica / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fusão Gênica / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França