The 1975 Japanese diet has a stress reduction effect in mice: search for physiological effects using metabolome analysis.
Biosci Biotechnol Biochem
; 82(4): 709-715, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29307274
ABSTRACT
We aimed to find new physiological effects of the Japanese diet. First, to determine the key components in serum from mice fed the 1975 diet, serum from mice fed the 1960, 1975, 1990 or 2005 Japanese diet was analyzed using CE-TOFMS and LC-TOFMS. Based on these results, the key components were determined by principal component analysis. Among the identified compounds, GABA was included. Therefore, a stress reduction effect was inferred as a novel physiological effect of this diet. Next, we tested whether the 1975 diet had an actual stress reduction effect in mice. Mice were given the 1975 diet or a control diet for 4 weeks, after which they were divided into restraint stress and non-stress groups. Mice fed the 1975 diet had significantly decreased stress parameters compared with those fed the control diet. These results provide the first evidence that the 1975 Japanese diet has a stress reduction effect.
Palavras-chave
CE-TOFMS(capillary electrophoresis time-of-flight mass spectrometry); CE-TOFMS: capillary electrophoresis time-of-flight mass spectrometry; HMT: Human Metabolome Technologies Inc.; LC-TOFMS(liquid chromatography time-of-flight mass spectrometry); LC-TOFMS: liquid chromatography time-of-flight mass spectrometry; NHNR: National Health and Nutrition Research; PCA: principal component analysis; PCs: Principal components; The Japanese diet; principal component analysis; stress
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Proteínas Sanguíneas
/
Dieta
/
Metabolômica
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Assunto da revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão