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Alkoxy Tetrazine Substitution at a Boron Center: A Strategy for Synthesizing Highly Fluorogenic Hydrophilic Probes.
Wu, Min; Wu, Xiaoai; Wang, Yayue; Gu, Lei; You, Jiao; Wu, Haoxing; Feng, Ping.
Afiliação
  • Wu M; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, West China Medical School, Sichuan University, 001 Forth Keyuan Road, 610041, Chengdu, P.R. China.
  • Wu X; Department of Nuclear Medicine, West China Hospital, Sichuan University, Sichuan, 610041, P.R. China.
  • Wang Y; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, West China Medical School, Sichuan University, 001 Forth Keyuan Road, 610041, Chengdu, P.R. China.
  • Gu L; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, West China Medical School, Sichuan University, 001 Forth Keyuan Road, 610041, Chengdu, P.R. China.
  • You J; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, West China Medical School, Sichuan University, 001 Forth Keyuan Road, 610041, Chengdu, P.R. China.
  • Wu H; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, West China Medical School, Sichuan University, 001 Forth Keyuan Road, 610041, Chengdu, P.R. China.
  • Feng P; Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.
Chembiochem ; 19(6): 530-534, 2018 03 16.
Article em En | MEDLINE | ID: mdl-29314618
ABSTRACT
Strongly fluorogenic boron dipyrromethene (BODIPY)-tetrazine probes have been obtained by introducing an alkoxy tetrazine fragment at the boron center. The fluorescence signal from these probes strongly increases by up to 225-fold after reaction with bioorthogonal coupling partners, and the hydrophilicity of probes is improved, such that they are suitable for live-cell imaging.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetrazóis / Osso e Ossos / Álcoois / Corantes Fluorescentes Limite: Humans Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetrazóis / Osso e Ossos / Álcoois / Corantes Fluorescentes Limite: Humans Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article