Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy.
Biomater Sci
; 6(3): 473-477, 2018 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-29436537
Herein, the photosensitizer indocyanine green (ICG) is used to induce the self-assembly of antigens to form nanovaccines. Under near-infrared (NIR) laser irradiation, reactive oxygen species can be generated by nanovaccines to disrupt the membranes of endo/lysosomes, which helps to release antigens into the cytosol efficiently, thereby enhancing antigen cross-presentation and anti-cancer immunity. To the best of our knowledge, this study represents the first example of ICG as a biocompatible adjuvant to improve cancer vaccine efficacy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fármacos Fotossensibilizantes
/
Vacinas Anticâncer
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Imunoterapia
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Verde de Indocianina
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Antígenos
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Neoplasias Experimentais
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biomater Sci
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China