Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease.

Zhang, Yue-Yue; Yang, Man; Bao, Jin-Fang; Gu, Li-Jie; Yu, Hong-Lei; Yuan, Wei-Jie

Zhang, Yue-Yue; Yang, Man; Bao, Jin-Fang; Gu, Li-Jie; Yu, Hong-Lei; Yuan, Wei-Jie.

Afiliação

Zhang YY; Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medcine, Haining Road 100rd, Hongkou Distrinct, Shanghai, 200080, China.
Yang M; Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medcine, Haining Road 100rd, Hongkou Distrinct, Shanghai, 200080, China.
Bao JF; Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medcine, Haining Road 100rd, Hongkou Distrinct, Shanghai, 200080, China.
Gu LJ; Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medcine, Haining Road 100rd, Hongkou Distrinct, Shanghai, 200080, China.
Yu HL; Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medcine, Haining Road 100rd, Hongkou Distrinct, Shanghai, 200080, China.
Yuan WJ; Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medcine, Haining Road 100rd, Hongkou Distrinct, Shanghai, 200080, China. ywj4169@163.com.

BMC Nephrol ; 19(1): 45, 2018 02 27.

Article em En | MEDLINE | ID: mdl-29486729

Assuntos

Autofagia/efeitos dos fármacos; Hiperfosfatemia/metabolismo; Fibras Musculares Esqueléticas/metabolismo; Atrofia Muscular/metabolismo; Fosfatos/toxicidade; Insuficiência Renal Crônica/metabolismo; Animais; Autofagia/fisiologia; Linhagem Celular Transformada; Hiperfosfatemia/induzido quimicamente; Hiperfosfatemia/patologia; Fibras Musculares Esqueléticas/efeitos dos fármacos; Fibras Musculares Esqueléticas/patologia; Músculo Esquelético/metabolismo; Músculo Esquelético/patologia; Atrofia Muscular/induzido quimicamente; Atrofia Muscular/patologia; Ratos; Insuficiência Renal Crônica/patologia

Palavras-chave

Autophagy; Cell atrophy; Chronic kidney disease; Hyperphosphatemia; Muscle wasting

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Autofagia / Atrofia Muscular / Fibras Musculares Esqueléticas / Insuficiência Renal Crônica / Hiperfosfatemia Limite: Animals Idioma: En Revista: BMC Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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