Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17.
Euro Surveill
; 23(8)2018 02.
Article
em En
| MEDLINE
| ID: mdl-29486829
ABSTRACT
IntroductionSeasonal influenza vaccination is widely recommended for people with risk factors, especially for people who are elderly. However, influenza vaccine effectiveness (IVE) varies year after year because of the variable antigenic composition of the circulating viruses and the vaccine composition. Methods:
We summarise the results of IVE and the impact of previous vaccination among subjects 60 years of age and over in a multicentre prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI) in Spain. We applied the test-negative design taking laboratory-confirmed influenza as outcome and vaccination status as exposure. Information about potential confounders was obtained from clinical registries or directly from patients.Results:
Adjusted IVE was 19% (95% confidence interval (CI) -15 to 43). For patients vaccinated in the current season but not in the two previous seasons, effectiveness was 49% (95% CI -20 to 78) and for patients vaccinated in the current and any of two previous seasons, effectiveness was 29% (95% CI -3 to 52). For those patients not vaccinated in the current season but vaccinated in any of the two previous seasons, effectiveness was 53% (95% CI 8 to 76).Conclusions:
Our data show a low vaccine effectiveness for the 2016/17 influenza season.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
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Vacinação
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Influenza Humana
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Vírus da Influenza A Subtipo H3N2
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Hospitalização
Tipo de estudo:
Observational_studies
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Risk_factors_studies
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Screening_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Euro Surveill
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha