Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.

Binder, Randall J; Hatfield, M Jason; Chi, Liying; Potter, Philip M

Binder, Randall J; Hatfield, M Jason; Chi, Liying; Potter, Philip M.

Afiliação

Binder RJ; Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: Randall.binder@stjude.org.
Hatfield MJ; Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: Jason.hatfield@stjude.org.
Chi L; Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: Liying.chi@stjude.org.
Potter PM; Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: Phil.potter@stjude.org.

Eur J Med Chem ; 149: 79-89, 2018 Apr 10.

Article em En | MEDLINE | ID: mdl-29499489

Assuntos

Abietanos/síntese química; Carboxilesterase/antagonistas & inibidores; Técnicas de Química Sintética/métodos; Fenantrenos/química; Abietanos/química; Inibidores Enzimáticos/síntese química; Humanos; Métodos; Naftoquinonas; Relação Estrutura-Atividade

Palavras-chave

Abietane analogues; Carboxylesterase; Enzyme inhibition; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrenos / Abietanos / Carboxilesterase / Técnicas de Química Sintética Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article

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