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LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3.
Ye, Buqing; Liu, Benyu; Yang, Liuliu; Zhu, Xiaoxiao; Zhang, Dongdong; Wu, Wei; Zhu, Pingping; Wang, Yanying; Wang, Shuo; Xia, Pengyan; Du, Ying; Meng, Shu; Huang, Guanling; Wu, Jiayi; Chen, Runsheng; Tian, Yong; Fan, Zusen.
Afiliação
  • Ye B; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Liu B; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Yang L; University of Chinese Academy of Sciences, Beijing, China.
  • Zhu X; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Zhang D; University of Chinese Academy of Sciences, Beijing, China.
  • Wu W; Laboratory Animal Center, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Zhu P; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Wang Y; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Wang S; University of Chinese Academy of Sciences, Beijing, China.
  • Xia P; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Du Y; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Meng S; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Huang G; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Wu J; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Chen R; Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Tian Y; Laboratory Animal Center, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Fan Z; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
EMBO J ; 37(8)2018 04 13.
Article em En | MEDLINE | ID: mdl-29535137
ABSTRACT
Divergent long noncoding RNAs (lncRNAs) represent a major lncRNA biotype in mouse and human genomes. The biological and molecular functions of the divergent lncRNAs remain largely unknown. Here, we show that lncKdm2b, a divergent lncRNA for Kdm2b gene, is conserved among five mammalian species and highly expressed in embryonic stem cells (ESCs) and early embryos. LncKdm2b knockout impairs ESC self-renewal and causes early embryonic lethality. LncKdm2b can activate Zbtb3 by promoting the assembly and ATPase activity of Snf2-related CREBBP activator protein (SRCAP) complex in trans Zbtb3 potentiates the ESC self-renewal in a Nanog-dependent manner. Finally, Zbtb3 deficiency impairs the ESC self-renewal and early embryonic development. Therefore, our findings reveal that lncRNAs may represent an additional layer of the regulation of ESC self-renewal and early embryogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a DNA / Células-Tronco Embrionárias / RNA Longo não Codificante Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a DNA / Células-Tronco Embrionárias / RNA Longo não Codificante Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China