Nitric oxide involvement in additive antidepressant-like effect of agmatine and lithium in mice forced swim test.
Psychiatry Res
; 266: 262-268, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29573854
ABSTRACT
Lithium is still the main agent in the management of mood disorders such as depression. Likewise, agmatine protects the central nervous system (CNS) against depression. The aim of the present study was to examine the possible additive antidepressant-like effect of agmatine and lithium in mice forced swim test (FST) as well as exploration of the probable involvement of nitric oxide (NO) pathway in this response. Results showed that pretreatment with a subeffective dose of agmatine (0.01â¯mg/kg) augmented the antidepressant-like effect of lithium subeffective dose (3â¯mg/kg) (Pâ¯<â¯0.001). L-NG-nitroarginine methyl ester (L-NAME, nonspecific nitric oxide synthase [NOS] inhibitor) at doses of 10 and 30â¯mg/kg, and 7-nitroindazole (7-NI, neuronal NOS inhibitor) at doses of 15 and 30â¯mg/kg potentiated the antidepressant-like effect of the subeffective combination of lithium (3â¯mg/kg) and agmatine (0.001â¯mg/kg) (Pâ¯<â¯0.001, Pâ¯<â¯0.01, respectively). However, various doses of aminoguanidine (25 and 50â¯mg/kg, inducible NOS inhibitor) failed to alter the immobility time of the same combination (Pâ¯>â¯0.05). Moreover, pretreatment with subeffective doses of L-arginine (substrate for NOS, 300 and 750â¯mg/kg) reversed the augmenting antidepressant-like effect of agmatine (0.01â¯mg/kg) on lithium (3â¯mg/kg) (Pâ¯<â¯0.001). Our results revealed that agmatine enhances the antidepressant-like effects of lithium and the NO pathway might mediate this phenomenon. In addition, constitutive NOS plays a dramatic role in this response.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Compostos de Lítio
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Agmatina
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Antidepressivos
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Psychiatry Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Irã