The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin.

Sadik, Christian D; Miyabe, Yoshishige; Sezin, Tanya; Luster, Andrew D

Sadik, Christian D; Miyabe, Yoshishige; Sezin, Tanya; Luster, Andrew D.

Afiliação

Sadik CD; Department of Dermatology, Allergy, and Venereology University of Lübeck, 23538, Lübeck, Germany. Electronic address: Christian.Sadik@uksh.de.
Miyabe Y; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sezin T; Department of Dermatology, Allergy, and Venereology University of Lübeck, 23538, Lübeck, Germany.
Luster AD; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Semin Immunol ; 37: 21-29, 2018 06.

Article em En | MEDLINE | ID: mdl-29602515

Assuntos

Doenças Autoimunes/imunologia; Complemento C5a/metabolismo; Inflamação/imunologia; Neutrófilos/imunologia; Receptor da Anafilatoxina C5a/metabolismo; Animais; Autoanticorpos/metabolismo; Autoimunidade; Movimento Celular; Modelos Animais de Doenças; Humanos; Leucotrieno B4/metabolismo; Camundongos; Ativação de Neutrófilo; Transdução de Sinais

Palavras-chave

Autoantibodies; Autoantibody-driven tissue inflammation; Autoimmune disease; BLT1; Bullous pemphigoid; C5a; C5a/LTB4 axis; C5aR1; C5aR2; Chemoattractants; Chemokines; Complement; Coversin; Epidermolysis bullosa acquisita; Extravasation; K/BxN model; Leukotriene B4; Lipid-cytokine-chemokine cascade; Neutrophil migration; Neutrophils; Pemphigoid diseases; Rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Complemento C5a / Receptor da Anafilatoxina C5a / Inflamação / Neutrófilos Limite: Animals / Humans Idioma: En Revista: Semin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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