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In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics.
Rigolin, Gian Matteo; Saccenti, Elena; Guardalben, Emanuele; Cavallari, Maurizio; Formigaro, Luca; Zagatti, Barbara; Visentin, Andrea; Mauro, Francesca R; Lista, Enrico; Bassi, Cristian; Lupini, Laura; Quaglia, Francesca Maria; Urso, Antonio; Bardi, Maria Antonella; Bonaldi, Laura; Volta, Eleonora; Tammiso, Elisa; Ilari, Caterina; Cafforio, Luciana; Melandri, Aurora; Cavazzini, Francesco; Negrini, Massimo; Semenzato, Gianpietro; Trentin, Livio; Foà, Robin; Cuneo, Antonio.
Afiliação
  • Rigolin GM; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Saccenti E; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Guardalben E; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Cavallari M; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Formigaro L; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Zagatti B; Department of Morphology, Surgery and Experimental Medicine, and "Laboratorio per le Tecnologie delle Terapie Avanzate" (LTTA), University of Ferrara, Ferrara, Italy.
  • Visentin A; Division of Haematology, Department of Medicine, University of Padua, Padua, Italy.
  • Mauro FR; Haematology, Department of Biomedical Sciences and Haematology, "Sapienza" University, Rome, Italy.
  • Lista E; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Bassi C; Department of Morphology, Surgery and Experimental Medicine, and "Laboratorio per le Tecnologie delle Terapie Avanzate" (LTTA), University of Ferrara, Ferrara, Italy.
  • Lupini L; Department of Morphology, Surgery and Experimental Medicine, and "Laboratorio per le Tecnologie delle Terapie Avanzate" (LTTA), University of Ferrara, Ferrara, Italy.
  • Quaglia FM; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Urso A; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Bardi MA; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Bonaldi L; Immunology and Molecular Immunology Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy.
  • Volta E; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Tammiso E; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Ilari C; Haematology, Department of Biomedical Sciences and Haematology, "Sapienza" University, Rome, Italy.
  • Cafforio L; Haematology, Department of Biomedical Sciences and Haematology, "Sapienza" University, Rome, Italy.
  • Melandri A; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Cavazzini F; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
  • Negrini M; Department of Morphology, Surgery and Experimental Medicine, and "Laboratorio per le Tecnologie delle Terapie Avanzate" (LTTA), University of Ferrara, Ferrara, Italy.
  • Semenzato G; Division of Haematology, Department of Medicine, University of Padua, Padua, Italy.
  • Trentin L; Division of Haematology, Department of Medicine, University of Padua, Padua, Italy.
  • Foà R; Haematology, Department of Biomedical Sciences and Haematology, "Sapienza" University, Rome, Italy.
  • Cuneo A; Haematology Section, Department of Medical Sciences, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.
Br J Haematol ; 181(2): 229-233, 2018 04.
Article em En | MEDLINE | ID: mdl-29611195
ABSTRACT
Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P = 0·025) and a shorter time to first treatment (P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high-risk CLL patients with distinct clinical and biological characteristics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / RNA Neoplásico / Leucemia Linfocítica Crônica de Células B / Regulação Leucêmica da Expressão Gênica / Aberrações Cromossômicas Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Haematol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / RNA Neoplásico / Leucemia Linfocítica Crônica de Células B / Regulação Leucêmica da Expressão Gênica / Aberrações Cromossômicas Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Haematol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália