SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells.

Janin, Alexandre; Bauer, Delphine; Ratti, Francesca; Valla, Camille; Bertrand, Anne; Christin, Emilie; Chopin, Emilie; Streichenberger, Nathalie; Bonne, Gisèle; Gache, Vincent; Cohen, Tatiana; Méjat, Alexandre

Janin, Alexandre; Bauer, Delphine; Ratti, Francesca; Valla, Camille; Bertrand, Anne; Christin, Emilie; Chopin, Emilie; Streichenberger, Nathalie; Bonne, Gisèle; Gache, Vincent; Cohen, Tatiana; Méjat, Alexandre.

Afiliação

Janin A; University of Lyon, University of Lyon1 Claude Bernard Lyon1, Institut NeuroMyoGene, CNRS UMR5310, INSERM U1217, Lyon, France. alexandre.janin01@chu-lyon.fr.
Bauer D; Laboratoire de Cardiogénétique Moléculaire, Centre de Biologie et Pathologie Est, Hospices Civils de Lyon, F-69677, Bron, France. alexandre.janin01@chu-lyon.fr.
Ratti F; University of Lyon, University of Lyon1 Claude Bernard Lyon1, Institut NeuroMyoGene, CNRS UMR5310, INSERM U1217, Lyon, France.
Valla C; University of Lyon, University of Lyon1 Claude Bernard Lyon1, Institut NeuroMyoGene, CNRS UMR5310, INSERM U1217, Lyon, France.
Bertrand A; University of Lyon, University of Lyon1 Claude Bernard Lyon1, Institut NeuroMyoGene, CNRS UMR5310, INSERM U1217, Lyon, France.
Christin E; Sorbonne Université, INSERM UMRS_974, Center of Research in Myology, 75013, Paris, France.
Chopin E; University of Lyon, University of Lyon1 Claude Bernard Lyon1, Institut NeuroMyoGene, CNRS UMR5310, INSERM U1217, Lyon, France.
Streichenberger N; Centre de Biotechnologie Cellulaire, Centre de Biologie et Pathologie Est, Hospices Civils de Lyon, F-69677, Bron, France.
Bonne G; University of Lyon, University of Lyon1 Claude Bernard Lyon1, Institut NeuroMyoGene, CNRS UMR5310, INSERM U1217, Lyon, France.
Gache V; Centre de Neuropathologie Est, Centre de Biologie et Pathologie Est, Hospices Civils de Lyon, F-69677, Bron, France.
Cohen T; Sorbonne Université, INSERM UMRS_974, Center of Research in Myology, 75013, Paris, France.
Méjat A; University of Lyon, University of Lyon1 Claude Bernard Lyon1, Institut NeuroMyoGene, CNRS UMR5310, INSERM U1217, Lyon, France.

Sci Rep ; 8(1): 5618, 2018 04 04.

Article em En | MEDLINE | ID: mdl-29618840

Assuntos

Proteína Morfogenética Óssea 4/metabolismo; Diferenciação Celular; Lamina Tipo A/metabolismo; Distrofia Muscular de Emery-Dreifuss/patologia; Mutação; Mioblastos/patologia; Proteína Smad6/metabolismo; Adulto; Animais; Proteína Morfogenética Óssea 4/genética; Estudos de Casos e Controles; Humanos; Lamina Tipo A/genética; Masculino; Camundongos; Camundongos Knockout; Desenvolvimento Muscular; Distrofia Muscular de Emery-Dreifuss/genética; Distrofia Muscular de Emery-Dreifuss/metabolismo; Mioblastos/metabolismo; Proteína Smad6/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Distrofia Muscular de Emery-Dreifuss / Mioblastos / Lamina Tipo A / Proteína Smad6 / Proteína Morfogenética Óssea 4 / Mutação Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Animals / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França

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