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Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
Ding, Li; Bailey, Matthew H; Porta-Pardo, Eduard; Thorsson, Vesteinn; Colaprico, Antonio; Bertrand, Denis; Gibbs, David L; Weerasinghe, Amila; Huang, Kuan-Lin; Tokheim, Collin; Cortés-Ciriano, Isidro; Jayasinghe, Reyka; Chen, Feng; Yu, Lihua; Sun, Sam; Olsen, Catharina; Kim, Jaegil; Taylor, Alison M; Cherniack, Andrew D; Akbani, Rehan; Suphavilai, Chayaporn; Nagarajan, Niranjan; Stuart, Joshua M; Mills, Gordon B; Wyczalkowski, Matthew A; Vincent, Benjamin G; Hutter, Carolyn M; Zenklusen, Jean Claude; Hoadley, Katherine A; Wendl, Michael C; Shmulevich, Llya; Lazar, Alexander J; Wheeler, David A; Getz, Gad.
Afiliação
  • Ding L; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington Univ
  • Bailey MH; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  • Porta-Pardo E; Barcelona Supercomputing Centre, 08034 Barcelona, Spain; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  • Thorsson V; Institute for Systems Biology, Seattle, WA 98109, USA.
  • Colaprico A; Machine Learning Group (MLG), Département d'Informatique, Université Libre de Bruxelles, 1050 Brussels, Belgium; Department of Human Genetics, University of Miami, Miami, FL 33136, USA.
  • Bertrand D; Computational and Systems Biology, Genome Institute of Singapore, Singapore, 13862.
  • Gibbs DL; Institute for Systems Biology, Seattle, WA 98109, USA.
  • Weerasinghe A; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  • Huang KL; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  • Tokheim C; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Cortés-Ciriano I; Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
  • Jayasinghe R; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  • Chen F; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • Yu L; H3 Biomedicine Inc., Cambridge, MA 02139, USA.
  • Sun S; Department of Radiation Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
  • Olsen C; Machine Learning Group (MLG), Département d'Informatique, Université Libre de Bruxelles, 1050 Brussels, Belgium.
  • Kim J; Broad Institute, Cambridge, MA 02142, USA.
  • Taylor AM; Broad Institute, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
  • Cherniack AD; Broad Institute, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
  • Akbani R; Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77498, USA.
  • Suphavilai C; Computational and Systems Biology, Genome Institute of Singapore, Singapore, 13862.
  • Nagarajan N; Computational and Systems Biology, Genome Institute of Singapore, Singapore, 13862.
  • Stuart JM; Baskin School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
  • Mills GB; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77498, USA.
  • Wyczalkowski MA; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  • Vincent BG; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Hutter CM; National Human Genome Research Institute, Bethesda, MD 20892, USA.
  • Zenklusen JC; National Cancer Institute, Bethesda, MD 20892, USA.
  • Hoadley KA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Wendl MC; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • Shmulevich L; Institute for Systems Biology, Seattle, WA 98109, USA.
  • Lazar AJ; Departments of Pathology, Genomic Medicine, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77498, USA.
  • Wheeler DA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: wheeler@bcm.edu.
  • Getz G; Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA; Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: gadgetz@broadinstitute.org.
Cell ; 173(2): 305-320.e10, 2018 04 05.
Article em En | MEDLINE | ID: mdl-29625049
ABSTRACT
The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Carcinogênese / Neoplasias Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Carcinogênese / Neoplasias Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article