Influence of protein properties and protein modification on biodistribution and tumor uptake of anticancer antibodies, antibody derivatives, and non-Ig scaffolds.

Warnders, Frank-Jan; Lub-de Hooge, Marjolijn N; de Vries, Elisabeth G E; Kosterink, Jos G W

Warnders, Frank-Jan; Lub-de Hooge, Marjolijn N; de Vries, Elisabeth G E; Kosterink, Jos G W.

Afiliação

Warnders FJ; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Lub-de Hooge MN; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
de Vries EGE; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Kosterink JGW; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Med Res Rev ; 38(6): 1837-1873, 2018 09.

Article em En | MEDLINE | ID: mdl-29635825

Assuntos

Anticorpos Monoclonais/metabolismo; Imunoglobulinas/metabolismo; Neoplasias/metabolismo; Proteínas Recombinantes/uso terapêutico; Animais; Humanos; Proteínas Recombinantes/farmacocinética; Distribuição Tecidual

Palavras-chave

biodistribution; drug; modification; molecular imaging; protein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes / Imunoglobulinas / Anticorpos Monoclonais / Neoplasias Limite: Animals / Humans Idioma: En Revista: Med Res Rev Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda

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