Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of <i>mec</i> Genes.

Argudín, M Angeles; Roisin, S; Nienhaus, L; Dodémont, M; de Mendonça, R; Nonhoff, C; Deplano, A; Denis, O

Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes.

Argudín, M Angeles; Roisin, S; Nienhaus, L; Dodémont, M; de Mendonça, R; Nonhoff, C; Deplano, A; Denis, O.

Afiliação

Argudín MA; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium maria.argudin@erasme.ulb.ac.be.
Roisin S; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Nienhaus L; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Dodémont M; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
de Mendonça R; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Nonhoff C; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Deplano A; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Denis O; National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Antimicrob Agents Chemother ; 62(7)2018 07.

Article em En | MEDLINE | ID: mdl-29661881

ABSTRACT

ABSTRACT

Methicillin-resistant Staphylococcus aureus isolates lacking mec genes (n = 32), collected from Belgian hospitals, were characterized for their ß-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction (gdpP and yjbH). Twelve isolates were ß-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter.

Assuntos

Antibacterianos/farmacologia; Proteínas de Bactérias/genética; Cefoxitina/farmacologia; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Staphylococcus aureus Resistente à Meticilina/genética; Oxacilina/farmacologia; Proteínas de Ligação às Penicilinas/genética; Resistência beta-Lactâmica/genética; Humanos; Staphylococcus aureus Resistente à Meticilina/isolamento & purificação; Testes de Sensibilidade Microbiana; Estudos Retrospectivos; Infecções Estafilocócicas/tratamento farmacológico; Infecções Estafilocócicas/microbiologia; beta-Lactamases/genética

Palavras-chave

BORSA; MODSA; PBP; ß-lactamase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxacilina / Proteínas de Bactérias / Cefoxitina / Resistência beta-Lactâmica / Proteínas de Ligação às Penicilinas / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Tipo de estudo: Observational_studies Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Bélgica

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