Cutaneous Metastasis of Adenocarcinoma of the Ampulla of Vater.
Am J Dermatopathol
; 40(10): 758-761, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-29672360
ABSTRACT
Cutaneous metastases from an adenocarcinoma of the Ampulla of Vater are very rare, with only a few cases previously reported. We present here an additional case in a 57-year-old woman who complained of a painful growth on her frontal scalp that she had noticed 4 months earlier. Her medical history included an ampullary adenocarcinoma, which was diagnosed 4 years ago, excised through a Whipple procedure, and treated using chemotherapy and radiotherapy. The scalp biopsy showed a dermal and epidermotropic well-differentiated glandular neoplasm with abundant neutrophils within the luminae of the tumoral glands. The tumor failed to express p63 and cytokeratin 5/6, whereas it was intensively positive for CK7 and E-cadherin. CDX2 expression was weak and focal. The immunohistochemical expression of DNA mismatch-repair proteins (MSH2, MSH6, MLH1, and PMS2) was preserved. Despite oncological treatment, the patient developed multiple cutaneous metastases during the ensuing several months, and eventually died 6 years after her initial diagnosis with widespread metastases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Couro Cabeludo
/
Neoplasias Cutâneas
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Ampola Hepatopancreática
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Adenocarcinoma
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Neoplasias do Sistema Digestório
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Neoplasias de Cabeça e Pescoço
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Am J Dermatopathol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha